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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-26717
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Abstract
In a steady-state GTPase activity assay, N-[3-(1H-imidazol-4-yl) propyl)]guanidines and N-G-acylated derivatives are more potent and efficacious at fusion proteins of guinea pig (gpH(2)R-G(s alpha S)) than human (hH(2)R-G(s alpha S)) histamine H-2 receptor, coupled to the short splice variant of G(s alpha), G(s alpha S). Whereas Ala-271 (hH(2)R) and Asp-271 (gpH(2)R) in transmembrane domain 7 ...

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