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Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors

URN to cite this document:
urn:nbn:de:bvb:355-epub-26721
DOI to cite this document:
10.5283/epub.2672
Xie, Sheng-Xue ; Schalkhausser, Fabian ; Ye, Qi-Zhuang ; Seifert, Roland ; Buschauer, Armin
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Date of publication of this fulltext: 05 Aug 2009 13:40


Abstract

Imidazolylpropylguanidines derived from impromidine and arpromidine are more potent and efficacious agonists at the guinea pig histamine H-2 receptor (gpH(2)R) than at the human H,R (hH(2)R) in the GTPase assay. Additionally, such guanidines are histamine H, receptor (H,R) antagonists with preference for the human relative to the guinea pig receptor. The purpose of this study was to examine ...

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