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Effects of Impromidine- and Arpromidine-Derived Guanidines on Recombinant Human and Guinea Pig Histamine H₁ and H₂ Receptors

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Xie, Sheng-Xue ; Schalkhausser, Fabian ; Ye, Qi-Zhuang ; Seifert, Roland ; Buschauer, Armin
Date of publication of this fulltext: 05 Aug 2009 13:40


Imidazolylpropylguanidines derived from impromidine and arpromidine are more potent and efficacious agonists at the guinea pig histamine H₂ receptor (gpH₂R) than at the human H₂R (hH₂R) in the GTPase assay. Additionally, such guanidines are histamine H₁ receptor (H₁R) antagonists with preference for the human relative to the guinea pig receptor. The purpose of this study was to examine ...


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