Relative bioavailability of three cefixime formulations

URN to cite this document:: urn:nbn:de:bvb:355-epub-268323
DOI to cite this document:: 10.5283/epub.26832

Kees, Frieder K. ; Naber, K. G. ; Sigl, G. ; Ungethüm, W. ; Grobecker, H. F.

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Date of publication of this fulltext: 29 Nov 2012 12:44

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Abstract

Three galenic formulations of cefixime (tablet, syrup and dry suspension) containing 200 mg each were compared with respect to their relative bioavailability in twelve healthy volunteers. All three formulations showed reliable absorption. Mean peak plasma concentrations were reached after 3.3-3.5 h, mean terminal half lives were 2.9-3.1 h. 18-24% of the dose administered were recovered unchanged ...