Pharmakokinetik von Cefixim bei Probanden und ein Literaturvergleich mit neuen Ester Prodrug Cephalosporinen [Pharmacokinetics of cefixime in volunteers and a literature comparison with the new ester prodrug cephalosporins]

URN to cite this document:

urn:nbn:de:bvb:355-epub-268356 Copy

DOI to cite this document:

10.5283/epub.26835 Copy

Kees, Frieder K. ; Naber, K. G.

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Date of publication of this fulltext: 30 Nov 2012 07:21

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Details

Item type:	Article
Journal or Publication Title:	Infection
Publisher:	MMV Medizin Verlag/Springer
Volume:	18 Suppl 3
Page Range:	S150-S154
Date:	1990
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:	Value Type 2079377 PubMed ID
Classification:	Notation Type Administration, Oral MESH Adult MESH Anti-Infective Agents/pharmacokinetics MESH Biological Availability MESH Cefixime MESH Cefotaxime/pharmacokinetics MESH Cephalosporins/pharmacokinetics MESH Esters MESH Female MESH Half-Life MESH Humans MESH Male MESH Molecular Structure MESH Prodrugs/pharmacokinetics MESH Solutions MESH Suspensions MESH Tablets MESH
Dewey Decimal Classification:	600 Technology > 615 Pharmacy
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	26835

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Abstract

The pharmacokinetic parameters of cefixime were determined in healthy volunteers following oral administration of 200 mg cefixime as tablet, syrup and dry suspension, respectively. All three galenic formulations showed reliable absorption. Mean peak plasma concentrations amounted to 2.4-3.4 mg/l and were reached after 3.3-3.5 h. Mean terminal half-lives were 2.9-3.1 h. The mean areas under the ...

Abstract

The pharmacokinetic parameters of cefixime were determined in healthy volunteers following oral administration of 200 mg cefixime as tablet, syrup and dry suspension, respectively. All three galenic formulations showed reliable absorption. Mean peak plasma concentrations amounted to 2.4-3.4 mg/l and were reached after 3.3-3.5 h. Mean terminal half-lives were 2.9-3.1 h. The mean areas under the plasma concentration-time curves ranged between 18 and 26 mg/l.h; 18-24% of the dose administered were recovered unchanged in the urine. The best bioavailability was obtained with the dry suspension followed by the tablet and the syrup. With respect to the ester pro-drug cephalosporins, cefuroxime axetil, cefetamet pivoxyl and cefotiam hexetil, cefixime exhibits higher plasma half-life and area under the curve as well as, comparable absolute bioavailability but consistently lower urinary recovery which indicates higher non-renal clearance.

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Metadata last modified: 26 Nov 2020 03:41

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