Enoxacin-Konzentrationen in der Samenflüssigkeit, im Prostatasekret und im Prostataadenomgewebe nach oraler Gabe oder intravenöser Infusion [Enoxacin concentration in seminal fluid, in prostate secretions and in prostatic adenoma tissue following oral administration or intravenous infusion]

URN to cite this document:

urn:nbn:de:bvb:355-epub-268409 Copy

DOI to cite this document:

10.5283/epub.26840 Copy

Naber, K. G. ; Sörgel, F. ; Kees, Frieder K. ; Schumacher, H. ; Sigl, G. ; Zürcher, J. ; Berger, S.

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Date of publication of this fulltext: 30 Nov 2012 10:49

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Details

Item type:	Article
Journal or Publication Title:	Infection
Publisher:	MMV Medizin Verlag/Springer
Volume:	17 Suppl 1
Page Range:	S30-S66
Date:	1989
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:	Value Type 2478481 PubMed ID
Classification:	Notation Type Administration, Oral MESH Adult MESH Aged MESH Body Fluids/analysis MESH Enoxacin/analysis MESH Humans MESH Infusions, Intravenous MESH Male MESH Middle Aged MESH Prostate/secretion MESH Prostatic Hyperplasia/metabolism MESH Semen/analysis MESH
Dewey Decimal Classification:	600 Technology > 615 Pharmacy
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	26840

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Abstract

In eleven volunteers and 39 patients undergoing transurethral resection of the prostate or bladder tumor, concentrations of enoxacin were measured in seminal fluid (volunteers), in prostatic fluid (volunteers, patients) and in prostatic adenoma tissue (patients) after oral (400 mg) administration and intravenous (428 mg) infusion (60 min) of enoxacin. Simultaneously 2.534 g of iothalamic acid was ...

Abstract

In eleven volunteers and 39 patients undergoing transurethral resection of the prostate or bladder tumor, concentrations of enoxacin were measured in seminal fluid (volunteers), in prostatic fluid (volunteers, patients) and in prostatic adenoma tissue (patients) after oral (400 mg) administration and intravenous (428 mg) infusion (60 min) of enoxacin. Simultaneously 2.534 g of iothalamic acid was i.v. injected to identify possible urinary contamination. The concentrations of enoxacin in seminal fluid after 2-4 h and in prostatic tissue after about 1-4 h and 14-16 h exceeded plasma concentrations more than two-fold. The concentrations in prostatic fluid after 1-4 h were about half the plasma concentrations. Venous blood samples were taken after intravenous infusion at intervals of up to 24 h in a total of 14 patients. The mean plasma concentration of enoxacin decreased from its maximum of 6.9 mg/l at the end of infusion to 0.5 mg/l at 12 h after administration. A terminal half life of 6.65 h was calculated according to an open two-compartment model.

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