Untersuchungen zur Bioverfügbarkeit von Heptaminol bei Probanden [Bioavailability of heptaminol in healthy subjects]

URN to cite this document:

urn:nbn:de:bvb:355-epub-268454 Copy

DOI to cite this document:

10.5283/epub.26845 Copy

Kees, Frieder K. ; Dominiak, P. ; Grobecker, H.

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Date of publication of this fulltext: 29 Nov 2012 12:41

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Details

Item type:	Article
Journal or Publication Title:	Arzneimittel-Forschung
Publisher:	Editio-Cantor-Verl./Thieme
Volume:	37
Number of Issue or Book Chapter:	10
Page Range:	pp. 1182-1185
Date:	1987
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:	Value Type 3435592 PubMed ID
Classification:	Notation Type Administration, Oral MESH Adult MESH Amino Alcohols/pharmacokinetics MESH Biological Availability MESH Chromatography, Thin Layer MESH Female MESH Half-Life MESH Heptaminol/urine MESH Humans MESH Male MESH
Dewey Decimal Classification:	600 Technology > 615 Pharmacy
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	26845

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Abstract

In ten healthy volunteers the plasma and urine concentrations of heptaminol (Heptylon) were determined by high-performance liquid chromatography after intravenous administration of 250 mg heptaminol and oral intake of 2 x 150 mg heptaminol in tablet form, and the pharmacokinetic parameters were calculated. Heptaminol was rapidly and entirely absorbed following oral administration of heptaminol. ...

Abstract

In ten healthy volunteers the plasma and urine concentrations of heptaminol (Heptylon) were determined by high-performance liquid chromatography after intravenous administration of 250 mg heptaminol and oral intake of 2 x 150 mg heptaminol in tablet form, and the pharmacokinetic parameters were calculated. Heptaminol was rapidly and entirely absorbed following oral administration of heptaminol. Mean plasma peak concentrations of 1.6 mg/l were reached after 1.8 h, the area under the plasma concentration-time curve was equal to that after intravenous administration. The dominant terminal plasma half-life was 2.5-2.7 h. The total clearance amounted to 700 ml/min, and nearly all the dose given was recovered unchanged in urine within 24 h, indicating renal elimination by glomerular filtration and tubular secretion without metabolization.

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Metadata last modified: 25 Nov 2020 15:29

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