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Effect of ketanserin on hemodynamics, plasma-catecholamine concentrations, and serotonin uptake by platelets in volunteers and patients with congestive heart failure

Grobecker, H., Gessler, I., Delius, W., Dominiak, P. and Kees, Frieder K. (1985) Effect of ketanserin on hemodynamics, plasma-catecholamine concentrations, and serotonin uptake by platelets in volunteers and patients with congestive heart failure. Journal of cardiovascular pharmacology 7, Suppl 7, S102-S104.

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Abstract

Ketanserin, which preferentially blocks 5-HT2-serotonergic receptors, was injected intravenously (i.v.) to patients with congestive heart failure in a bolus dose of 10 mg, followed by an i.v. infusion of 3 mg/h over a period of 4 h. The drug caused a decrease in total peripheral resistance and, conversely, an increase in stroke volume. Right atrial and pulmonary artery pressures were decreased. ...

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Item type:Article
Date:1985
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
2412024PubMed ID
Classification:
NotationType
AgedMESH
Blood Platelets/metabolismMESH
Catecholamines/bloodMESH
Dopamine/metabolismMESH
FemaleMESH
Heart Failure/physiopathologyMESH
Hemodynamics/drug effectsMESH
HumansMESH
KetanserinMESH
MaleMESH
Middle AgedMESH
Norepinephrine/metabolismMESH
Piperidines/pharmacologyMESH
Serotonin/bloodMESH
Serotonin Antagonists/pharmacologyMESH
Stroke Volume/drug effectsMESH
Vascular Resistance/drug effectsMESH
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:26854
Owner only: item control page

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