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Changes in peripheral and central catecholaminergic and serotoninergic neurons of rats after acute and subacute administration of nicotine

Dominiak, P. ; Kees, Frieder K. ; Grobecker, H.


To establish dose-response relationships for nicotine (acute and subacute administration), we measured hemodynamic parameters as well as circulating and tissue catecholamines in sympathetically innervated organs in rats. We also investigated nicotines's influence on adrenoceptor binding sites of the heart and on serotonin metabolism. In conscious and anesthetized rats, we found a dose-dependent ...


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