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Layer-by-Layer Coated Gold Nanoparticles: Size-Dependent Delivery of DNA into Cells

Elbakry, Asmaa Mohamed ; Wurster, Eva-Christina ; Zaky, Alaa ; Liebl, Renate ; Schindler, Edith ; Bauer-Kreisel, Petra ; Blunk, Torsten ; Rachel, Reinhard ; Goepferich, Achim ; Breunig, Miriam



Abstract

Because nanoparticles are finding uses in myriad biomedical applications, including the delivery of nucleic acids, a detailed knowledge of their interaction with the biological system is of utmost importance. Here the size-dependent uptake of gold nanoparticles (AuNPs) (20, 30, 50 and 80 nm), coated with a layer-by-layer approach with nucleic acid and poly(ethylene imine) (PEI), into a variety of ...

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