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Dissociations in the effects of beta2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: Support for the concept of functional selectivity

Brunskole Hummel, Irena, Kälble, Solveig, Burhenne, Heike, Reinartz, Michael T., Schwede, Frank, Buschauer, Armin and Seifert, Roland (2013) Dissociations in the effects of beta2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: Support for the concept of functional selectivity. PLoS One 8 (5), e64556.

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Date of publication of this fulltext: 26 Apr 2013 05:19

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Other URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064556


Abstract

In neutrophils, activation of the beta2-adrenergic receptor (beta2AR), a Gs-coupled receptor, inhibits inflammatory responses, which could be therapeutically exploited. The aim of this study was to evaluate the effects of various beta2AR ligands on adenosine-3',5'-cyclic monophosphate (cAMP) accumulation and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2*-) ...

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Item type:Article
Date:31 May 2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
doi:10.1371/journal.pone.0064556DOI
Keywords:β2-adrenergic receptor, neutrophil, adenosine-3',5'-cyclic monophosphate, superoxide anion, functional selectivity
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:27972
Owner only: item control page

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