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Dissociations in the effects of beta2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: Support for the concept of functional selectivity

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Brunskole Hummel, Irena ; Kälble, Solveig ; Burhenne, Heike ; Reinartz, Michael T. ; Schwede, Frank ; Buschauer, Armin ; Seifert, Roland
Date of publication of this fulltext: 26 Apr 2013 05:19


In neutrophils, activation of the beta2-adrenergic receptor (beta2AR), a Gs-coupled receptor, inhibits inflammatory responses, which could be therapeutically exploited. The aim of this study was to evaluate the effects of various beta2AR ligands on adenosine-3',5'-cyclic monophosphate (cAMP) accumulation and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2*-) ...


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