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Population pharmacokinetics and pharmacodynamic evaluation of intravenous and enteral moxifloxacin in surgical intensive care unit patients

Kees, Martin Georg ; Schaeftlein, André ; Haeberle, Helene Anna ; Kees, Frieder K. ; Kloft, Charlotte ; Heininger, Alexandra


OBJECTIVES: To describe the plasma concentration-time profile of moxifloxacin after intravenous and enteral administration in intensive care unit (ICU) patients and to provide a pharmacodynamic (PD) evaluation with regard to pneumonia. PATIENTS AND METHODS: Twenty-five adult patients from a cardiothoracic/mixed surgical ICU were enrolled. Moxifloxacin was given as a standard dose (400 mg once ...


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