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Radioligand binding and reporter gene assays for histamine H3 and H4 receptor species orthologs

Nordemann, Uwe (2013) Radioligand binding and reporter gene assays for histamine H3 and H4 receptor species orthologs. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Apr 2013 14:26

Abstract (English)

G-protein coupled receptors (GPCRs) represent the most important class of drug targets for the currently available pharmacotherapeutics. In the histamine receptor (HR) field, antagonists of H1 and H2 receptors are well established drugs for many decades, whereas the more recently identified H3 (H3R) and H4 receptors (H4R) are considered promising biological targets for drug discovery programs. ...

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Translation of the abstract (German)

G-Protein gekoppelte Rezeptoren (GPCRs) stellen die wichtigste Klasse von Zielproteinen für die derzeit verfügbaren Pharmakotherapeutika dar. Auf dem Gebiet der Histaminrezeptoren (HR) sind Antagonisten des H1 und H2 Rezeptors seit Jahrzehnten bewährte Arzneimittel, während die erst kürzlich identifizierten H3 (H3R) und H4 Rezeptoren (H4R) als vielversprechende neue biologische Zielmoleküle ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2013
Referee:Prof. Dr. Armin Buschauer
Date of exam:4 April 2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:histamine H4 receptor, histamine H3 receptor, luciferase, reporter gene assay, radioligand binding assay, cAMP responsive element, receptor species orthologs, HEK293T cells
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28048
Owner only: item control page

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