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Dimeric argininamide-type neuropeptide Y receptor antagonists: chiral discrimination between Y1 and Y4 receptors

Keller, Max ; Kaske, Melanie ; Holzammer, Tobias ; Bernhardt, Günther ; Buschauer, Armin



Abstract

The structurally related peptides neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) are endogenous agonists of the NPY receptor (YR) family, which in humans comprises four functionally expressed subtypes, designated Y1R, Y2R, Y4R and Y5R. Non-peptide antagonists with high affinity and selectivity have been described for the Y1R, Y2R and Y5R, but such compounds are still ...

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