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Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts

Nordemann, Uwe, Wifling, David, Schnell, David, Bernhardt, Günther, Stark, Holger, Seifert, Roland and Buschauer, Armin (2013) Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts. PLoS One 8 (9), e73961.

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Date of publication of this fulltext: 26 Jul 2013 06:33

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Abstract

The investigation of the (patho)physiological role of the histamine H4 receptor (H4R) and its validation as a possible drug target in translational animal models are compromised by distinct species-dependent discrepancies regarding potencies and receptor subtype selectivities of the pharmacological tools. Such differences were extremely pronounced in case of proximal readouts, e. g. [32P]GTPase ...

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Item type:Article
Date:2 September 2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie, Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0073961DOI
24023919PubMed ID
PMC3759464PubMedCentral-ID
Keywords:histamine, Histamine H4 receptor, luciferase reporter gene assay, receptor species orthologs, HEK293 cells
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28434
Owner only: item control page

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