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Luciferase reporter gene assay on human, murine and rat histamine H4 receptor orthologs: correlations and discrepancies between distal and proximal readouts

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Nordemann, Uwe ; Wifling, David ; Schnell, David ; Bernhardt, Günther ; Stark, Holger ; Seifert, Roland ; Buschauer, Armin
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 26 Jul 2013 06:33


The investigation of the (patho)physiological role of the histamine H4 receptor (H4R) and its validation as a possible drug target in translational animal models are compromised by distinct species-dependent discrepancies regarding potencies and receptor subtype selectivities of the pharmacological tools. Such differences were extremely pronounced in case of proximal readouts, e. g. [32P]GTPase ...


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