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Homology modeling, molecular dynamics simulations and site-directed mutagenesis of histamine H2 receptors

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Holzammer, Tobias
Date of publication of this fulltext: 16 Aug 2013 12:13

Abstract (English)

G-protein coupled receptors (GPCR) are the most important drug target family in humans. In the last decades, our knowledge about GPCR structure, conformational states, activation and their role in signal transduction has substantially increased. A huge number of novel agonists, antagonists and inverse agonists, including bivalent and functionally selective ligands, has been developed. More ...


Translation of the abstract (German)

G-protein gekoppelte Rezeptoren (GPCR) gehören zu den wichtigsten Zielproteinen für Arzneistoffe. In den letzten Jahrzehnten nahm unser Wissen über Struktur, Konformationszustände und Aktivierung von GPCR sowie über ihre Rolle in der Signaltransduktion bedeutend zu. Eine Vielzahl von Agonisten, Antagonisten und inversen Agonisten, einschließlich bivalenter und funktionell selektiver Liganden ...


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