Go to content
UR Home

Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane- and cis-cyclopentane β-amino acids shifts selectivity toward the Y4 receptor

Berlicki, Lukasz ; Kaske, Melanie ; Gutierrez-Abad, Raquel ; Bernhardt, Günther ; Illa, Ona ; Ortuño, Rosa ; Cabrele, Chiara ; Buschauer, Armin ; Reiser, Oliver



Abstract

Neuropeptide Y (NPY) and pancreatic polypeptide (PP) control central and peripheral processes by activating the G protein coupled receptors YxR (x = 1,2,4,5). We present analogs of the C-terminal fragments 25-36 and 32-36 of NPY and PP containing (1R,2S)-cyclobutane (βCbu) or (1R,2S)-cyclopentane (βCpe), which display exclusively Y4R affinity. In particular, [βCpe34]-NPY-(25-36) is a Y4R ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons