Go to content
UR Home

Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane- and cis-cyclopentane β-amino acids shifts selectivity toward the Y4 receptor

Berlicki, Lukasz, Kaske, Melanie, Gutierrez-Abad, Raquel, Bernhardt, Günther, Illa, Ona, Ortuño, Rosa, Cabrele, Chiara, Buschauer, Armin and Reiser, Oliver (2013) Replacement of Thr32 and Gln34 in the C-terminal neuropeptide Y fragment 25-36 by cis-cyclobutane- and cis-cyclopentane β-amino acids shifts selectivity toward the Y4 receptor. Journal of Medicinal Chemistry 56 (21), pp. 8422-8431.

Full text not available from this repository.

at publisher (via DOI)

at PubMed


Abstract

Neuropeptide Y (NPY) and pancreatic polypeptide (PP) control central and peripheral processes by activating the G protein coupled receptors YxR (x = 1,2,4,5). We present analogs of the C-terminal fragments 25-36 and 32-36 of NPY and PP containing (1R,2S)-cyclobutane (βCbu) or (1R,2S)-cyclopentane (βCpe), which display exclusively Y4R affinity. In particular, [βCpe34]-NPY-(25-36) is a Y4R ...

plus


Export bibliographical data



Item type:Article
Date:3 September 2013
Additional Information (public):Supporting Information available
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands"
Identification Number:
ValueType
10.1021/jm4008505DOI
24090364PubMed ID
Related URLs:
URLURL Type
http://pubs.acs.org/doi/pdf/10.1021/jm4008505Publisher
http://pubs.acs.org/doi/suppl/10.1021/jm4008505Publisher
Keywords:Neuropeptide Y, pancreatic polypeptide, Y receptors, Y4 receptor, beta-amino acid, gamma-amino acid, cyclobutane, cyclopentane, pentacin
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28752
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons