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Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor

Wittmann, Hans-Joachim, Seifert, Roland and Strasser, Andrea (2014) Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor. In silico pharmacology 2.

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Date of publication of this fulltext: 23 Jun 2014 12:39

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Other URL: http://www.in-silico-pharmacology.com/content/2/1/1


Abstract

Purpose It was shown by several experimental studies that some G protein coupled receptors (GPCR) are sensitive to sodium ions. Furthermore, mutagenesis studies or the determination of crystal structures of the adenosine A2A or δ-opioid receptor revealed an allosteric Na+ binding pocket near to the highly conserved Asp2.50. Within a previous study, the influence of NaCl concentration onto the ...

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Item type:Article
Date:24 May 2014
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s40203-014-0001-yDOI
Keywords:Histamine H3 receptor Na+-sensitivity Mathematical model Molecular dynamics
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30099
Owner only: item control page

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