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Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor

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Wittmann, Hans-Joachim ; Seifert, Roland ; Strasser, Andrea
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 23 Jun 2014 12:39


Purpose It was shown by several experimental studies that some G protein coupled receptors (GPCR) are sensitive to sodium ions. Furthermore, mutagenesis studies or the determination of crystal structures of the adenosine A2A or δ-opioid receptor revealed an allosteric Na+ binding pocket near to the highly conserved Asp2.50. Within a previous study, the influence of NaCl concentration onto the ...


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