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Molecular tools for G-protein coupled receptors:
Synthesis, pharmacological characterization and [3H]-labeling of subtype-selective ligands for histamine H4 and NPY Y2 receptors

URN to cite this document:
urn:nbn:de:bvb:355-epub-305058
Baumeister, Paul
Date of publication of this fulltext: 01 Aug 2014 15:37


Abstract (English)

G-protein coupled receptors (GPCRs) are the most important class of biological targets of approved pharmacotherapeutics and hold great potential for the development of future drugs as well. Histamine and neuropeptide Y (NPY) receptors are representative examples of aminergic and peptidergic GPCRs, respectively. Even though the histamine H4 receptor (H4R) has been suggested as a potential ...

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Translation of the abstract (German)

G-Protein-gekoppelte Rezeptoren (GPCRs) sind die wichtigste Klasse biologischer Zielstrukturen für zugelassene Pharmaka und besitzen ein großes Potenzial für die Entwicklung neuer Arzneistoffe. Histamin- und Neuropeptid Y (NPY)-Rezeptoren sind repräsentative Beispiele aminerger und peptiderger GPCRs. Auch wenn der Histamin H4-Rezeptor (H4R) als ein potenzieller therapeutischer Angriffspunkt für ...

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