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Discrimination of steatosis and NASH in mice using nuclear magnetic resonance spectroscopy

Klein, Matthias S. ; Dorn, Christoph ; Saugspier, Michael Sebastian ; Hellerbrand, Claus ; Oefner, Peter J. ; Gronwald, Wolfram


Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic dysfunction. The disease spectrum ranges from hepatic steatosis to nonalcoholic steatohepatitis (NASH). The aim of this study was to identify metabolic differences in murine models of simple hepatic steatosis and NASH for the distinction of these NAFLD stages. For 12 weeks, male BALB/c mice were fed either a control or two ...


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