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Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

Dietl, Katrin, Renner, Kathrin, Dettmer, Katja, Timischl, Birgit, Eberhart, Karin, Dorn, Christoph , Hellerbrand, Claus, Kastenberger, Michael, Kunz-Schughart, Leoni A., Oefner, Peter J., Andreesen, Reinhard, Gottfried, Eva and Kreutz, Marina (2010) Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. Journal of immunology 184 (3), pp. 1200-1209.

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Other URL: http://doi.org/10.4049/jimmunol.0902584


Abstract

High concentrations of lactic acid (LA) are found under various pathophysiological conditions and are accompanied by an acidification of the environment. To study the impact of LA on TNF secretion, human LPS-stimulated monocytes were cultured with or without LA or the corresponding pH control. TNF secretion was significantly suppressed by low concentrations of LA (< or = 10 mM), whereas only ...

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Item type:Article
Date:February 2010
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
ValueType
20026743PubMed ID
10.4049/jimmunol.0902584DOI
Classification:
NotationType
Acidosis, Lactic/metabolismMESH
Cell Line, TumorMESH
Cell Survival/immunologyMESH
Cells, CulturedMESH
Coculture TechniquesMESH
Energy Metabolism/immunologyMESH
Glycolysis/immunologyMESH
Growth Inhibitors/pharmacologyMESH
HumansMESH
Immunosuppressive Agents/toxicityMESH
Lactic Acid/toxicityMESH
Melanoma/secretionMESH
Monocytes/secretionMESH
Reactive Oxygen Species/metabolismMESH
Tumor Necrosis Factor-alpha/secretionMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30636
Owner only: item control page
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