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Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

Dietl, Katrin ; Renner, Kathrin ; Dettmer, Katja ; Timischl, Birgit ; Eberhart, Karin ; Dorn, Christoph ; Hellerbrand, Claus ; Kastenberger, Michael ; Kunz-Schughart, Leoni A. ; Oefner, Peter J. ; Andreesen, Reinhard ; Gottfried, Eva ; Kreutz, Marina



Abstract

High concentrations of lactic acid (LA) are found under various pathophysiological conditions and are accompanied by an acidification of the environment. To study the impact of LA on TNF secretion, human LPS-stimulated monocytes were cultured with or without LA or the corresponding pH control. TNF secretion was significantly suppressed by low concentrations of LA (< or = 10 mM), whereas only ...

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