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Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

Dietl, Katrin, Renner, Kathrin, Dettmer, Katja, Timischl, Birgit, Eberhart, Karin, Dorn, Christoph , Hellerbrand, Claus, Kastenberger, Michael, Kunz-Schughart, Leoni A., Oefner, Peter J., Andreesen, Reinhard, Gottfried, Eva and Kreutz, Marina (2010) Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. Journal of immunology 184 (3), pp. 1200-1209.

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Other URL: http://doi.org/10.4049/jimmunol.0902584


High concentrations of lactic acid (LA) are found under various pathophysiological conditions and are accompanied by an acidification of the environment. To study the impact of LA on TNF secretion, human LPS-stimulated monocytes were cultured with or without LA or the corresponding pH control. TNF secretion was significantly suppressed by low concentrations of LA (< or = 10 mM), whereas only ...


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Item type:Article
Date:February 2010
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
20026743PubMed ID
Acidosis, Lactic/metabolismMESH
Cell Line, TumorMESH
Cell Survival/immunologyMESH
Cells, CulturedMESH
Coculture TechniquesMESH
Energy Metabolism/immunologyMESH
Growth Inhibitors/pharmacologyMESH
Immunosuppressive Agents/toxicityMESH
Lactic Acid/toxicityMESH
Reactive Oxygen Species/metabolismMESH
Tumor Necrosis Factor-alpha/secretionMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30636
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