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Functionalized derivatives of 1,4-dimethylnaphthalene as precursors for biomedical applications: synthesis, structures, spectroscopy and photochemical activation in the presence of dioxygen

Posavec, Damir, Zabel, Manfred, Bogner, Udo, Bernhardt, Günther and Knör, Günther (2012) Functionalized derivatives of 1,4-dimethylnaphthalene as precursors for biomedical applications: synthesis, structures, spectroscopy and photochemical activation in the presence of dioxygen. Organic & biomolecular chemistry 10 (35), pp. 7062-7069.

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Abstract

Decomposition of endoperoxide containing molecules is an attractive approach for the delayed release of singlet oxygen under mild reaction conditions. Here we describe a new method for the adaptation of the corresponding decay times by controlling the supramolecular functional structure of the surrounding matrix in the immediate vicinity of embedded singlet oxygen precursors. Thus, a significant ...

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Item type:Article
Date:2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
22847738PubMed ID
10.1039/c2ob26236cDOI
Classification:
NotationType
Antineoplastic Agents/pharmacologyMESH
Breast Neoplasms/drug therapyMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Crystallography, X-RayMESH
Delayed-Action Preparations/chemistryMESH
FemaleMESH
HumansMESH
Methylene Blue/pharmacologyMESH
Models, MolecularMESH
Naphthalenes/chemistryMESH
Oxygen/chemistryMESH
Photosensitizing Agents/pharmacologyMESH
Singlet Oxygen/pharmacologyMESH
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30686
Owner only: item control page

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