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No evidence for histamine H4-receptor in human monocytes

Werner, Kristin ; Neumann, Detlef ; Buschauer, Armin ; Seifert, Roland



Abstract

The histamine H4-receptor (H4R) is a classic pertussis toxin-sensitive Gi-protein-coupled receptor that mediates increases in intracellular calcium concentration (Ca2+i). The presence of the H4R in human eosinophils has been rigorously documented by several independent groups. It has also been suggested that the H4R is expressed in human monocytes, but this suggestion hinges, in part, on H4R ...

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