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Sodium binding to hH3R and hH4R - a molecular modelling study

Wittmann, Hans-Joachim ; Seifert, Roland ; Strasser, Andrea



Abstract

Several aminergic GPCRs, e.g., the human histamine H-3-receptor (hH(3)R) are sensitive to sodium ions. Based on these experimental results, including site directed mutagenesis studies, a sodium binding pocket near to the highly conserved Asp(2.50) was suggested. Recently, in the crystallized adenosine A(2A) receptor (4EIY), a sodium ion was found in a pocket, coordinated by Asp(52), Ser(91), and ...

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