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Sodium binding to hH3R and hH4R - a molecular modelling study

Wittmann, Hans-Joachim, Seifert, Roland and Strasser, Andrea (2014) Sodium binding to hH3R and hH4R - a molecular modelling study. Journal of Molecular Modeling 20, p. 2394.

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Abstract

Several aminergic GPCRs, e.g., the human histamine H3-receptor (hH3R) are sensitive to sodium ions. Based on these experimental results, including site directed mutagenesis studies, a sodium binding pocket near to the highly conserved Asp2.50 was suggested. Recently, in the crystallized adenosine A2A receptor (4EIY), a sodium ion was found in a pocket, coordinated by Asp52, Ser91, and three water ...

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Item type:Article
Date:2014
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1007/s00894-014-2394-2DOI
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30746
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