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Sodium binding to hH3R and hH4R - a molecular modelling study

Wittmann, Hans-Joachim ; Seifert, Roland ; Strasser, Andrea


Several aminergic GPCRs, e.g., the human histamine H3-receptor (hH3R) are sensitive to sodium ions. Based on these experimental results, including site directed mutagenesis studies, a sodium binding pocket near to the highly conserved Asp2.50 was suggested. Recently, in the crystallized adenosine A2A receptor (4EIY), a sodium ion was found in a pocket, coordinated by Asp52, Ser91, and three water ...


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