Obreque-Balboa, José-Esteban, Sun, Qiu, Bernhardt, Günther, König, Burkhard and Buschauer, Armin (2016) Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization. European Journal of Medicinal Chemistry 109, pp. 124-133.
Full text not available from this repository.
Abstract
A series of chromones, bearing substituted amino groups or N-substituted carboxamide moieties in position 2, was synthesized and characterized in cellular assays for modulation of the ABC transporters-ABCC1 (MDCKII-MRP1 cells), ABCB1 (Kb-V1 cells) and ABCG2 (MCF-7/Topo cells). The most potent ABCC1 modulators identified among these flavonoid-type compounds were comparable to the reference ...
Export bibliographical data
| Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Date: | 2016 | ||||||
| Additional Information (public): | Supplementary Material available online | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König | ||||||
| Identification Number: |
| ||||||
| Related URLs: |
| ||||||
| Keywords: | ABCB1; ABCG2; ABCC1; ABC transporters;BCRP; chromone; flavonoid; inhibitors; MDR; modulators; MRP1;multidrug resistance-associated protein 1; p-glycoprotein; reversan; synthesis | ||||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 31956 |
Owner only: item control page
Altmetric