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Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization

Obreque-Balboa, José-Esteban ; Sun, Qiu ; Bernhardt, Günther ; König, Burkhard ; Buschauer, Armin


A series of chromones, bearing substituted amino groups or N-substituted carboxamide moieties in position 2, was synthesized and characterized in cellular assays for modulation of the ABC transporters ABCC1 (MDCKII-MRP1 cells), ABCB1 (Kb-V1 cells) and ABCG2 (MCF-7/Topo cells). The most potent ABCC1 modulators identified among these flavonoid-type compounds were comparable to the reference ...


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