Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome

URN to cite this document:: urn:nbn:de:bvb:355-epub-327508
DOI to cite this document:: 10.5283/epub.32750

Weber, Daniela ; Oefner, Peter J.

; Hiergeist, Andreas ; Koestler, Josef ; Gessner, Andre ; Weber, Markus ; Hahn, Joachim ; Wolff, Daniel ; Stämmler, Frank ; Spang, Rainer ; Herr, Wolfgang ; Dettmer, Katja

; Holler, Ernst

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Date of publication of this fulltext: 12 Nov 2015 14:21

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Abstract

Indole, which is produced from L-tryptophan by commensal bacteria expressing tryptophanase, not only is an important intercellular signal in microbial communities, but also modulates mucosal barrier function and expression of pro-and anti-inflammatory genes by intestinal epithelial cells. Here, we hypothesized that decreased urinary excretion of 3-indoxyl sulfate (3-IS), the major conjugate of ...