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Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome

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Weber, Daniela ; Oefner, Peter J. ; Hiergeist, Andreas ; Koestler, Josef ; Gessner, Andre ; Weber, Markus ; Hahn, Joachim ; Wolff, Daniel ; Stämmler, Frank ; Spang, Rainer ; Herr, Wolfgang ; Dettmer, Katja ; Holler, Ernst
Date of publication of this fulltext: 12 Nov 2015 14:21


Urinary 3-IS levels predict outcome after ASCT and are associated with antibiotics and NOD2/CARD15 variants.Publisher’s Note: There is an Inside Blood Commentary on this article in this issue.Indole, which is produced from l-tryptophan by commensal bacteria expressing tryptophanase, not only is an important intercellular signal in microbial communities, but also modulates mucosal barrier function ...


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