Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models

URN to cite this document:: urn:nbn:de:bvb:355-epub-329102
DOI to cite this document:: 10.5283/epub.32910

Pirkl, Martin ; Hand, E. ; Kube, D. ; Spang, Rainer

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Date of publication of this fulltext: 27 Nov 2015 14:21

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Abstract

Motivation: Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Effect Models are an alternative. They derive the network structure indirectly from ...