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Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor.

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Lübker, Carolin ; Dove, Stefan ; Tang, Wei-Jen ; Bieber Urbauer, Ramona J. ; Moskovitz, Jackob ; Urbauer, Jeffrey L. ; Seifert, Roland
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Date of publication of this fulltext: 22 Dec 2015 13:37


Bacillus anthracis adenylyl cyclase toxin edema factor (EF) is one component of the anthrax toxin and is essential for establishing anthrax disease. EF activation by the eukaryotic Ca2+-sensor calmodulin (CaM) leads to massive cAMP production resulting in edema. cAMP also inhibits the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, thus reducing production of reactive oxygen species ...


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