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Arthritis and cholinergic transition of sympathetic nerve fibers

Stangl, Hubert Werner (2016) Arthritis and cholinergic transition of sympathetic nerve fibers. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Jan 2016 12:52

Abstract (German)

Fragestellung. Die Dichte von sympathischen Nervenfasern, welche über die Expression von Tyrosin-hydroxylase (TH, Schlüsselenzym der Katecholaminbiosynthese) analysiert wird, ist bei Arthritis im entzündeten Gewebe erniedrigt. Allerdings ist bekannt, dass sympathische Nervenfasern unter bestimmten Bedingungen, wie sie beispielsweise während der Innervierung von sich entwickelnden Schweißdrüsen ...


Translation of the abstract (English)

Objective. Density of sympathetic nerve fibers decreases in inflamed arthritic tissue, which is tested by detection of tyrosine-hydroxylase (TH, key enzyme of catecholamine synthesis). However, under certain circumstances like during the innervation phase of developing sweat glands or in periosteum, sympathetic nerve fibers can change phenotype from catecholaminergic to cholinergic. Therefore, ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:14 January 2016
Referee:Prof. Dr. Jens Schlossmann and Prof. Dr. Rainer H. Straub
Date of exam:29 October 2015
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Keywords:peripheral nervous system; sympathetic; catecholaminergic; cholinergic; transition; nerve fiber; arthritis; rheumatoid; inflammation; ganglia; osteoclast; bone; synovial; tyrosine hydroxylase; vesicular acetylcholine transporter; leukemia inhibitory factor;
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33126
Owner only: item control page


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