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BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells

Edalat, Lena ; Stegen, Benjamin ; Klumpp, Lukas ; Haehl, Erik ; Schilbach, Karin ; Lukowski, Robert ; Kühnle, Matthias ; Bernhardt, Günther ; Buschauer, Armin ; Zips, Daniel ; Ruth, Peter ; Huber, Stephan M.



Abstract

Infiltration of the brain by glioblastoma cells reportedly requires Ca2+ signals and BK K+ channels that program and drive glioblastoma cell migration, respectively. Ionizing radiation (IR) has been shown to induce expression of the chemokine SDF-1, to alter the Ca2+ signaling, and to stimulate cell migration of glioblastoma cells. Here, we quantified fractionated IR-induced migration/brain ...

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