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BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells

Edalat, Lena, Stegen, Benjamin, Klumpp, Lukas, Haehl, Erik, Schilbach, Karin, Lukowski, Robert, Kühnle, Matthias, Bernhardt, Günther, Buschauer, Armin, Zips, Daniel, Ruth, Peter and Huber, Stephan M. (2016) BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells. Oncotarget 7 (12), pp. 14259-14278.

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Abstract

Infiltration of the brain by glioblastoma cells reportedly requires Ca2+ signals and BK K+ channels that program and drive glioblastoma cell migration, respectively. Ionizing radiation (IR) has been shown to induce expression of the chemokine SDF-1, to alter the Ca2+ signaling, and to stimulate cell migration of glioblastoma cells. Here, we quantified fractionated IR-induced migration/brain ...

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Item type:Article
Date:16 February 2016
Additional Information (public):Supporting Information available
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.18632/oncotarget.7423DOI
26893360PubMed ID
Related URLs:
URLURL Type
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=7423&path[]=21362Publisher
Keywords:fura-2 Ca2+ imaging, transfilter migration, tumor invasion, CXCL12 chemokine, KCNMA1
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:33217
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