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Mimicking of arginine by functionalized Nω-carbamoylated arginine as a new broadly applicable approach to labeled bioactive peptides: high affinity angiotensin, neuropeptide Y, neuropeptide FF and neurotensin receptor ligands as examples

Keller, Max ; Kuhn, Kilian K. ; Einsiedel, Jürgen ; Hübner, Harald ; Biselli, Sabrina ; Mollereau, Catherine ; Wifling, David ; Svobodova, Jaroslava ; Bernhardt, Günther ; Cabrele, Chiara ; Vanderheyden, Patrick ; Gmeiner, Peter ; Buschauer, Armin



Abstract

Derivatization of biologically active peptides by conjugation with fluorophores or radionuclide-bearing moieties is an effective and commonly used approach to prepare molecular tools and diagnostic agents. Whereas lysine, cysteine, and N-terminal amino acids have been mostly used for peptide conjugation, we describe a new, widely applicable approach to peptide conjugation based on the ...

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