Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation

URN to cite this document:: urn:nbn:de:bvb:355-epub-334424
DOI to cite this document:: 10.5283/epub.33442

Merkl, Rainer ; Plach, Maximilian G. ; Reisinger, Bernd ; Sterner, Reinhard

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Date of publication of this fulltext: 29 Feb 2016 14:44

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Abstract

Modern enzymes are highly optimized biocatalysts that process their substrates with extreme efficiency. Many enzymes catalyze more than one reaction; however, the persistence of such ambiguities, their consequences and evolutionary causes are largely unknown. As a paradigmatic case, we study the history of bi-functionality for a time span of approximately two billion years for the sugar isomerase ...