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Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation

Merkl, Rainer, Plach, Maximilian G., Reisinger, Bernd and Sterner, Reinhard (2016) Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation. PLoS Genetics 12 (1), pp. 1-14.

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Date of publication of this fulltext: 29 Feb 2016 14:44

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Other URL: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005836


Abstract

Modern enzymes are highly optimized biocatalysts that process their substrates with extreme efficiency. Many enzymes catalyze more than one reaction; however, the persistence of such ambiguities, their consequences and evolutionary causes are largely unknown. As a paradigmatic case, we study the history of bi-functionality for a time span of approximately two billion years for the sugar isomerase ...

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Item type:Article
Date:29 January 2016
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pgen.1005836DOI
Article ID: e1005836Other
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33442
Owner only: item control page

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