Hochrein, Jochen, Zacharias, Helena, Taruttis, Franziska, Samol, Claudia, Engelmann, Julia C., Spang, Rainer, Oefner, Peter J. and Gronwald, Wolfram (2015) Data Normalization of (1)H NMR Metabolite Fingerprinting Data Sets in the Presence of Unbalanced Metabolite Regulation. J. Proteome Res. 14 (8), pp. 3217-3228.
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Other URL: http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.5b00192
Abstract
Data normalization is an essential step in NMR-based metabolomics. Conducted properly, it improves data quality and removes unwanted biases. The choice of the appropriate normalization method is critical and depends on the inherent properties of the data set in question. In particular, the presence of unbalanced metabolic regulation, where the different specimens and cohorts under investigation ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 7 August 2015 | ||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) | ||||
| Identification Number: |
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| Keywords: | NMR; data normalization; metabolomics; unbalanced regulation; confounding factors | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 33527 |
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