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Structure-Activity Relationships of Histamine H_2 Receptor Ligands,

Dove, Stefan ; Elz, Sigurd ; Seifert, Roland ; Buschauer, Armin


Recent research on histamine H2 receptor agonists was focused on quantitative structure-activity relationships and receptor models explaining the activity of imidazolylpropylguanidines. Their selectivity for guinea pig vs. human isoforms was investigated using H2 receptor-Gsalpha fusion proteins and attributed to amino acid differences in transmembrane domains 1 and 7. New antagonists result from ...


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