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Synthesis and pharmacological activity of fluorescent histamine H2 receptor antagonists related to potentidine,

Li, Liantao ; Kracht, Julia ; Peng, Shiqi ; Bernhardt, Günther ; Elz, Sigurd ; Buschauer, Armin



Abstract

Fluorescently labeled histamine H2 receptor antagonists were synthesized starting from N-cyano-N′-[3-(3-piperidin-1-ylmethylphenoxy)propyl]guanidines with an additional N″-ω-aminoalkyl substituent (chain lengths 2–8 methylene groups) or from 3-(3-piperidin-1-ylmethylphenoxy)propylamine. The primary amino group was derivatized with various fluorophores (fluorescein, acridine, dansyl, ...

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