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Investigations on histamine and neuropeptide Y receptors by label-free and label-dependent methods

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Lieb, Sebastian
Date of publication of this fulltext: 19 Oct 2016 14:06

Abstract (English)

Label-free cell-based assays have been attracting growing attention in drug research. In this context, optical approaches based on evanescent electric fields (e.g. resonant waveguide grating, RWG; dynamic mass redistribution, DMR) and electrochemical impedance analysis (e. g. electric cell-substrate impedance sensing, ECIS) are the most widespread techniques. The aim of this doctoral thesis was ...


Translation of the abstract (German)

Markierungsfreie zelluläre Assays sind in den letzten Jahren immer interessanter für die Arzneimittelforschung geworden. Von diesen neuen Analysetechniken sind die optischen- und impedanzbasierten Methoden am weitesten verbreitet. Ziel der Doktorarbeit war es, die optische (DMR; dynamic mass redistribution), sowie die impendanzbasierte markierungsfreie Analysemethode (ECIS, electric cell ...


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