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Investigations on histamine and neuropeptide Y receptors by label-free and label-dependent methods

URN to cite this document:
urn:nbn:de:bvb:355-epub-347387
DOI to cite this document:
10.5283/epub.34738
Lieb, Sebastian
Date of publication of this fulltext: 19 Oct 2016 14:06


Abstract (English)

Label-free cell-based assays have been attracting growing attention in drug research. In this context, optical approaches based on evanescent electric fields (e.g. resonant waveguide grating, RWG; dynamic mass redistribution, DMR) and electrochemical impedance analysis (e. g. electric cell-substrate impedance sensing, ECIS) are the most widespread techniques. The aim of this doctoral thesis was ...

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Translation of the abstract (German)

Markierungsfreie zelluläre Assays sind in den letzten Jahren immer interessanter für die Arzneimittelforschung geworden. Von diesen neuen Analysetechniken sind die optischen- und impedanzbasierten Methoden am weitesten verbreitet. Ziel der Doktorarbeit war es, die optische (DMR; dynamic mass redistribution), sowie die impendanzbasierte markierungsfreie Analysemethode (ECIS, electric cell ...

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