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Reference point insensitive molecular data analysis

Altenbuchinger, Michael, Rehberg, Thorsten, Zacharias, Helena, Stämmler, Frank, Dettmer, Katja , Weber, Daniela, Hiergeist, Andreas, Gessner, Andre, Holler, Ernst, Oefner, Peter J. and Spang, Rainer (2016) Reference point insensitive molecular data analysis. Bioinformatics.

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Date of publication of this fulltext: 14 Nov 2016 12:33

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Other URL: http://bioinformatics.oxfordjournals.org/content/early/2016/09/14/bioinformatics.btw598.full.pdf


Abstract

Motivation: In biomedicine, every molecular measurement is relative to a reference point, like a fixed aliquot of RNA extracted from a tissue, a defined number of blood cells, or a defined volume of biofluid. Reference points are often chosen for practical reasons. For example, we might want to assess the metabolome of a diseased organ but can only measure metabolites in blood or urine. In this ...

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Item type:Article
Date:16 September 2016
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
27634945PubMed ID
10.1093/bioinformatics/btw598DOI
Keywords:VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; LOGISTIC-REGRESSION; VARIABLE SELECTION; C-MYC; REGULARIZATION; MICROBIOME; LASSO;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34824
Owner only: item control page

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