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Reference point insensitive molecular data analysis

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Altenbuchinger, Michael ; Rehberg, Thorsten ; Zacharias, Helena ; Stämmler, Frank ; Dettmer, Katja ; Weber, Daniela ; Hiergeist, Andreas ; Gessner, Andre ; Holler, Ernst ; Oefner, Peter J. ; Spang, Rainer
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Date of publication of this fulltext: 14 Nov 2016 12:33


Motivation: In biomedicine, every molecular measurement is relative to a reference point, like a fixed aliquot of RNA extracted from a tissue, a defined number of blood cells, or a defined volume of biofluid. Reference points are often chosen for practical reasons. For example, we might want to assess the metabolome of a diseased organ but can only measure metabolites in blood or urine. In this ...


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