Reference point insensitive molecular data analysis

URN to cite this document:: urn:nbn:de:bvb:355-epub-348244
DOI to cite this document:: 10.5283/epub.34824

Altenbuchinger, Michael ; Rehberg, Thorsten ; Zacharias, Helena ; Stämmler, Frank ; Dettmer, Katja

; Weber, Daniela ; Hiergeist, Andreas ; Gessner, Andre ; Holler, Ernst ; Oefner, Peter J. ; Spang, Rainer

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Date of publication of this fulltext: 14 Nov 2016 12:33

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Abstract

Motivation: In biomedicine, every molecular measurement is relative to a reference point, like a fixed aliquot of RNA extracted from a tissue, a defined number of blood cells, or a defined volume of biofluid. Reference points are often chosen for practical reasons. For example, we might want to assess the metabolome of a diseased organ but can only measure metabolites in blood or urine. In this ...