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Epimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia

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Ruther, Joachim ; Hagström, Asa K. ; Brandstetter, Birgit ; Hofferberth, John ; Bruckmann, Astrid ; Semmelmann, Florian ; Fink, Michaela ; Lowack, Helena ; Laberer, Sabine ; Niehuis, Oliver ; Deutzmann, Rainer ; Löfstedt, Christer ; Sterner, Reinhard
Date of publication of this fulltext: 10 Feb 2017 11:14


Males of all species of the parasitic wasp genus Nasonia use (4R,5S)-5-hydroxy-4-decanolide (RS) as component of their sex pheromone while only N. vitripennis (Nv), employs additionally (4R,5R)-5-hydroxy-4-decanolide (RR). Three genes coding for the NAD(+)-dependent short-chain dehydrogenases/reductases (SDRs) NV10127, NV10128, and NV10129 are linked to the ability of Nv to produce RR. Here we ...


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