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Analysis of complex stability and allosteric interaction in the imidazole glycerol phosphate synthase complex

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Holinski, Alexandra
Date of publication of this fulltext: 04 Apr 2017 08:08

Abstract (German)

Imidazole glycerol phosphate synthase (ImGPS) is a bi-enzyme complex that consists of the glutaminase subunit HisH and the cyclase subunit HisF. HisH hydrolyzes glutamine to glutamate and ammonia, which is transported through a channel to the active site of HisF where it reacts with N´-[(5´-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide-ribonucleotide (PRFAR) to imidazole glycerol ...


Translation of the abstract (German)

Die Imidazolglycerolphosphat-Synthase (ImGPS) ist ein Bienzymkomplex, der aus der Glutaminase-Untereinheit HisH und der Zyklase-Untereinheit HisF besteht. HisH hydrolisiert Glutamin zu Glutamat und Ammoniak, das durch einen intermolekularen Kanal zum aktiven Zentrum von HisF diffundiert und dort mit [(5‘Phosphoribulosyl)formimino]-5-aminoimidazol-4-carboxamid-Ribonukleotid (PRFAR) zu ...


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