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Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling

Friedrich, Ulrike, Datta, Shyamtanu, Schubert, Thomas, Plößl, Karolina, Schneider, Magdalena, Grassmann, Felix, Fuchshofer, Rudolf, Tiefenbach, Klaus-Jürgen, Längst, Gernot and Weber, Bernhard H. F. (2015) Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling. Human Molecular Genetics 24, pp. 6361-6373.

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Abstract

High-temperature requirement A1 (HTRA1) is a secreted serine protease reported to play a role in the development of several cancers and neurodegenerative diseases. Still, the mechanism underlying the disease processes largely remains undetermined. In age-related macular degeneration (AMD), a common cause of vision impairment and blindness in industrialized societies, two synonymous polymorphisms ...

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Item type:Article
Date:2015
Institutions:Medicine > Lehrstuhl für Humangenetik
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie
Identification Number:
ValueType
10.1093/hmg/ddv346DOI
26310622PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35520
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