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Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling

Friedrich, Ulrike ; Datta, Shyamtanu ; Schubert, Thomas ; Plößl, Karolina ; Schneider, Magdalena ; Grassmann, Felix ; Fuchshofer, Rudolf ; Tiefenbach, Klaus-Jürgen ; Längst, Gernot ; Weber, Bernhard H. F.


High-temperature requirement A1 (HTRA1) is a secreted serine protease reported to play a role in the development of several cancers and neurodegenerative diseases. Still, the mechanism underlying the disease processes largely remains undetermined. In age-related macular degeneration (AMD), a common cause of vision impairment and blindness in industrialized societies, two synonymous polymorphisms ...


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