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Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients – thinking of clinically relevant CYP2D6 interactions

Paulzen, M., Haen, Ekkehard and Stegmann, Benedikt (2016) Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients – thinking of clinically relevant CYP2D6 interactions. Journal of Psychopharmacology 30, pp. 903-809.

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Date of publication of this fulltext: 08 May 2017 13:10

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Abstract

Background: Treatment of arterial hypertension in patients with severe mental illnesses often results in polypharmacy, potentially leading to drug-drug interactions. The objective of the study was to analyse the in vivo inhibitory potential of two antihypertensive drugs, amlodipine and metoprolol on CYP2D6 catalysed 9-hydroxylation of risperidone (RIS). Methods: A therapeutic drug monitoring ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
10.1177/0269881116650390DOI
Keywords:Therapeutic drug monitoring, risperidone, amlodipine, metoprolol, CYP2D6, interaction, pharmacokinetics
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35627
Owner only: item control page

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