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Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas

Maliniemi, P. , Laukkanen, K., Vakeva, L., Dettmer, Katja , Lipsanen, T., Jeskanen, L., Bessede, A., Oefner, Peter J., Kadin, M. E. and Ranki, A. (2017) Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas. Oncoimmunology 6 (3), e1273310.

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Other URL: http://www.tandfonline.com/doi/full/10.1080/2162402X.2016.1273310


Abstract

Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in several different subtypes of cutaneous T-cell lymphoma (CTCL), and evaluated the kynurenine (KYN) pathway in the local TME and in patient sera. Specimens ...

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Item type:Article
Date:10 February 2017
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
10.1080/2162402X.2016.1273310DOI
28405495PubMed ID
Keywords:INDOLEAMINE 2,3-DIOXYGENASE 1; TUMORAL IMMUNE RESISTANCE; CANCER-IMMUNOTHERAPY; HODGKIN-LYMPHOMA; EXPRESSION; PAPULOSIS; INFLAMMATION; INHIBITION; DISEASE; PROTEIN; Cutaneous T-cell lymphoma; immunosuppressive; microenvironment; indoleamine 2,3-dioxygenase1; kynurenine; tryptophan; 2,3-dioxygenase
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35719
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