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Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas

Maliniemi, P. ; Laukkanen, K. ; Vakeva, L. ; Dettmer, Katja ; Lipsanen, T. ; Jeskanen, L. ; Bessede, A. ; Oefner, Peter J. ; Kadin, M. E. ; Ranki, A.



Abstract

Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target. We studied the expression of both IDO1 and the related tryptophan 2,3-dioxygenase (TDO) in several different subtypes of cutaneous T-cell lymphoma (CTCL), and evaluated the kynurenine (KYN) pathway in the local TME and in patient sera. Specimens ...

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