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Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-Münster protocols

Rohde, M. ; Bonn, B. R. ; Zimmermann, M. ; Lange, J. ; Moricke, A. ; Klapper, W. ; Oschlies, I. ; Szczepanowski, M. ; Nagel, I. ; Schrappe, M. ; Loeffler, M. ; Siebert, R. ; Reiter, A. ; Burkhardt, B. ; Altenbuchinger, Michael ; Dettmer-Wilde, Katja ; Engelmann, Julia C. ; Gronwald, Wolfram ; Oefner, Peter J. ; Schwarzfischer, Philipp ; Taruttis, Franziska ; Spang, Rainer



Abstract

Burkitt's lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) are pathologically and clinically distinct subtypes of aggressive non-Hodgkin B-cell lymphoma. To learn more about their biology, we employed metabolomic and proteomic methods to study both established cell lines as well as cryopreserved and formalin-fixed paraffin-embedded (FFPE) tissue sections of BL and DLBCL. Strikingly, NMR ...

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