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Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints

Zacharias, Helena, Rehberg, Thorsten, Mehrl, S., Richtmann, D., Wettig, Tilo, Oefner, Peter J., Spang, Rainer, Gronwald, Wolfram and Altenbuchinger, Michael (2017) Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints. J. Proteome Res..

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Other URL: http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.7b00325


Abstract

Metabolomics data is typically scaled to a common reference like a constant volume of body fluid, a constant creatinine level, or a constant area under the spectrum. Such scaling of the data, however, may affect the selection of biomarkers and the biological interpretation of results in unforeseen ways. Here, we studied how both the outcome of hypothesis tests for differential metabolite ...

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Item type:Article
Date:21 August 2017
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
28825821PubMed ID
10.1021/acs.jproteome.7b00325DOI
Keywords:ACUTE KIDNEY INJURY; DATA NORMALIZATION; CARDIAC-SURGERY; DATA SETS; NMR; METABOLOMICS; REGRESSION; SELECTION; DISEASE; MODEL; metabolomics; NMR; LASSO; zero-sum; normalization; scaling
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36205
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