CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality

URN to cite this document:: urn:nbn:de:bvb:355-epub-365673
DOI to cite this document:: 10.5283/epub.36567

Hoffmeister, Helen ; Fuchs, Andreas

; Erdel, Fabian

; Pinz, Sophia ; Gröbner-Ferreira, Regina ; Bruckmann, Astrid ; Deutzmann, Rainer ; Schwartz, Uwe ; Maldonado, Rodrigo ; Huber, Claudia ; Dendorfer, Anne-Sarah ; Rippe, Karsten ; Längst, Gernot

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Date of publication of this fulltext: 23 Jan 2018 14:34

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Abstract

CHD3 and CHD4 (Chromodomain Helicase DNA binding protein), two highly similar representatives of the Mi-2 subfamily of SF2 helicases, are coexpressed in many cell lines and tissues and have been reported to act as the motor subunit of the NuRD complex (nucleosome remodeling and deacetylase activities). Besides CHD proteins, NuRD contains several repressors like HDAC1/2, MTA2/3 and MBD2/3, arguing ...