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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-373145
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.37314
Zusammenfassung
On the basis of the long-known prototypic pharmacophore 3-(1H-imidazol-4-yl) propylguanidine (SK&F 91486, 2), monomeric, homodimeric, and heterodimeric bisalkylguanidine-type histamine H-2 receptor (H2R) agonists with various alkyl spacers were synthesized. Aiming at increased H2R selectivity of the ligands, the imidazol-4-yl moiety was replaced by imidazol-1-yl, 2-aminothiazol-5-yl or ...
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