Establishing a Split Luciferase Assay for Proteinkinase G (PKG) Interaction Studies

URN to cite this document:: urn:nbn:de:bvb:355-epub-373592
DOI to cite this document:: 10.5283/epub.37359

Schramm, Andrea ; Mueller-Thuemen, Philip ; Littmann, Timo ; Harloff, Manuela ; Ozawa, Takeaki ; Schlossmann, Jens

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Date of publication of this fulltext: 23 May 2018 08:30

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Abstract

Nitric oxide (NO/cyclic guanosine monophosphate (cGMP)-regulated cellular mechanisms are involved in a variety of (patho-) physiological processes. One of the main effector molecules in this system, proteinkinase G (PKG), serves as a molecular switch by phosphorylating different target proteins and thereby turning them on or off. To date, only a few interaction partners of PKG have been described ...