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Imaging in Biologically-Relevant Environments with AFM Using Stiff qPlus Sensors

Pürckhauer, Korbinian , Weymouth, Alfred J. , Pfeffer, Katharina, Kullmann, Lars, Mulvihill, Estefania, Krahn, Michael P. , Müller, Daniel J. and Giessibl, Franz J. (2018) Imaging in Biologically-Relevant Environments with AFM Using Stiff qPlus Sensors. Scientific Reports 8 (1), p. 9330.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Jun 2018 13:20

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Other URL: http://doi.org/10.1038/s41598-018-27608-6, https://www.nature.com/articles/s41598-018-27608-6


High-resolution imaging of soft biological samples with atomic force microscopy (AFM) is challenging because they must be imaged with small forces to prevent deformation. Typically, AFM of those samples is performed with soft silicon cantilevers (k ≈ 0.1–10 N/m) and optical detection in a liquid environment. We set up a new microscope that uses a stiff qPlus sensor (k ≥ 1 kN/m). Several complex ...


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Item type:Article
Date:19 June 2018
Institutions:Physics > Institute of Experimental and Applied Physics > Chair Professor Giessibl > Group Franz J. Giessibl
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie
Projects:Open Access Publizieren (DFG)
Identification Number:
Dewey Decimal Classification:500 Science > 530 Physics
500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37415
Owner only: item control page


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