Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects

URN to cite this document:: urn:nbn:de:bvb:355-epub-374664
DOI to cite this document:: 10.5283/epub.37466

Mayr, Judith ; Bachl, Jürgen ; Schlossmann, Jens ; Díaz Díaz, David

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Date of publication of this fulltext: 05 Jul 2018 13:17

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Abstract

A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and ...