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Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects

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Mayr, Judith ; Bachl, Jürgen ; Schlossmann, Jens ; Díaz Díaz, David
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 05 Jul 2018 13:17


A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and ...


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