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Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand

Kneuttinger, Andrea C. ; Winter, Martin ; Simeth, Nadja Anita ; Heyn, Kristina ; Merkl, Rainer ; König, Burkhard ; Sterner, Reinhard


The artificial regulation of proteins by light is an emerging subdiscipline of synthetic biology. Here, we used this concept to photocontrol both catalysis and allostery within the heterodimeric enzyme complex imidazole glycerol phosphate synthase (ImGP-S). ImGP-S consists of the cyclase subunit HisF and the glutaminase subunit HisH, which is allosterically stimulated by substrate binding to ...


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