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Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand

Kneuttinger, Andrea C., Winter, Martin, Simeth, Nadja Anita , Heyn, Kristina , Merkl, Rainer , König, Burkhard and Sterner, Reinhard (2018) Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand. ChemBioChem.

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Abstract

The artificial regulation of proteins by light is an emerging subdiscipline of synthetic biology. Here, we used this concept to photocontrol both catalysis and allostery within the heterodimeric enzyme complex imidazole glycerol phosphate synthase (ImGP‐S). ImGP‐S consists of the cyclase subunit HisF and the glutaminase subunit HisH, which is allosterically stimulated by substrate binding to ...

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Item type:Article
Date:2018
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Chemistry and Pharmacy > Institut für Anorganische Chemie > Alumni or Retired Professors > Arbeitskreis Prof. Dr. Rainer Winter
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:DFG STE 891/12-1
Identification Number:
ValueType
10.1002/cbic.201800219DOI
Keywords:allosterism · enzyme catalysis · enzyme inhibitor · photoswitches · synthetic biology
Dewey Decimal Classification:500 Science > 530 Physics
500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37477
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