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Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression

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Feist, M. ; Schwarzfischer, Philipp ; Heinrich, Paul ; Sun, Xueni ; Kemper, J. ; von Bonin, F. ; Perez-Rubio, Paula ; Taruttis, Franziska ; Rehberg, Thorsten ; Dettmer, Katja ; Gronwald, Wolfram ; Reinders, Jörg ; Engelmann, Julia C. ; Dudek, J. ; Klapper, W. ; Trumper, L. ; Spang, Rainer ; Oefner, Peter J. ; Kube, D.
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Jul 2018 08:48


Knowledge of stromal factors that have a role in the transcriptional regulation of metabolic pathways aside from c-Myc is fundamental to improvements in lymphoma therapy. Using a MYC-inducible human B-cell line, we observed the cooperative activation of STAT3 and NF-kappa B by IL10 and CpG stimulation. We show that IL10 + CpG-mediated cell proliferation of MYClow cells depends on glutaminolysis. ...


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